November 18, 2022 Sebia, Inc. Karen Anderson Director of Regulatory 1705 Corporate Drive, Suite 400 Norcross, Georgia 30093 Re:
![PDF) Serum Free Light Chains in Neoplastic Monoclonal Gammopathies: Relative Under-Detection of Lambda Dominant Kappa/Lambda Ratio, and Underproduction of Free Lambda Light Chains, as Compared to Kappa Light Chains, in Patients With PDF) Serum Free Light Chains in Neoplastic Monoclonal Gammopathies: Relative Under-Detection of Lambda Dominant Kappa/Lambda Ratio, and Underproduction of Free Lambda Light Chains, as Compared to Kappa Light Chains, in Patients With](https://www.researchgate.net/publication/325548624/figure/tbl1/AS:669120521572363@1536542172993/Distribution-of-SFLCA-Results-of-Patients-With-Monoclonal-Gammopathies-Categorized-by_Q320.jpg)
PDF) Serum Free Light Chains in Neoplastic Monoclonal Gammopathies: Relative Under-Detection of Lambda Dominant Kappa/Lambda Ratio, and Underproduction of Free Lambda Light Chains, as Compared to Kappa Light Chains, in Patients With
![Flow cytometry remission by Ig light chains ratio is a powerful marker of outcome in multiple myeloma after tandem autologous transplant: a real-life study | Journal of Experimental & Clinical Cancer Research Flow cytometry remission by Ig light chains ratio is a powerful marker of outcome in multiple myeloma after tandem autologous transplant: a real-life study | Journal of Experimental & Clinical Cancer Research](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs13046-016-0324-0/MediaObjects/13046_2016_324_Fig1_HTML.gif)
Flow cytometry remission by Ig light chains ratio is a powerful marker of outcome in multiple myeloma after tandem autologous transplant: a real-life study | Journal of Experimental & Clinical Cancer Research
![Kappa and lambda immunohistochemistry and in situ hybridization in the evaluation of atypical cutaneous lymphoid infiltrates - Hristov - 2020 - Journal of Cutaneous Pathology - Wiley Online Library Kappa and lambda immunohistochemistry and in situ hybridization in the evaluation of atypical cutaneous lymphoid infiltrates - Hristov - 2020 - Journal of Cutaneous Pathology - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/ec451350-c748-4112-a036-ef938dcc377c/cup13858-fig-0002-m.jpg)
Kappa and lambda immunohistochemistry and in situ hybridization in the evaluation of atypical cutaneous lymphoid infiltrates - Hristov - 2020 - Journal of Cutaneous Pathology - Wiley Online Library
![Phenotyping Polyclonal Kappa and Lambda Light Chain Molecular Mass Distributions in Patient Serum Using Mass Spectrometry | Journal of Proteome Research Phenotyping Polyclonal Kappa and Lambda Light Chain Molecular Mass Distributions in Patient Serum Using Mass Spectrometry | Journal of Proteome Research](https://pubs.acs.org/cms/10.1021/pr5005967/asset/images/large/pr-2014-005967_0001.jpeg)
Phenotyping Polyclonal Kappa and Lambda Light Chain Molecular Mass Distributions in Patient Serum Using Mass Spectrometry | Journal of Proteome Research
![PDF) The cut-offs for kappa/lambda ratio in bone marrow immunohistochemistry for the diagnosis of multiple myeloma PDF) The cut-offs for kappa/lambda ratio in bone marrow immunohistochemistry for the diagnosis of multiple myeloma](https://i1.rgstatic.net/publication/343542653_The_cut-offs_for_kappalambda_ratio_in_bone_marrow_immunohistochemistry_for_the_diagnosis_of_multiple_myeloma/links/5f5a249b92851c078958bdf0/largepreview.png)
PDF) The cut-offs for kappa/lambda ratio in bone marrow immunohistochemistry for the diagnosis of multiple myeloma
Phenotyping Polyclonal Kappa and Lambda Light Chain Molecular Mass Distributions in Patient Serum Using Mass Spectrometry | Journal of Proteome Research
![Phenotyping Polyclonal Kappa and Lambda Light Chain Molecular Mass Distributions in Patient Serum Using Mass Spectrometry | Journal of Proteome Research Phenotyping Polyclonal Kappa and Lambda Light Chain Molecular Mass Distributions in Patient Serum Using Mass Spectrometry | Journal of Proteome Research](https://pubs.acs.org/cms/10.1021/pr5005967/asset/images/large/pr-2014-005967_0006.jpeg)
Phenotyping Polyclonal Kappa and Lambda Light Chain Molecular Mass Distributions in Patient Serum Using Mass Spectrometry | Journal of Proteome Research
![Phenotyping Polyclonal Kappa and Lambda Light Chain Molecular Mass Distributions in Patient Serum Using Mass Spectrometry | Journal of Proteome Research Phenotyping Polyclonal Kappa and Lambda Light Chain Molecular Mass Distributions in Patient Serum Using Mass Spectrometry | Journal of Proteome Research](https://pubs.acs.org/cms/10.1021/pr5005967/asset/images/medium/pr-2014-005967_0004.gif)
Phenotyping Polyclonal Kappa and Lambda Light Chain Molecular Mass Distributions in Patient Serum Using Mass Spectrometry | Journal of Proteome Research
Page 1 of 9 Title: Flow Cytometric Testing for Kappa and Lambda light chains Sponsored and reviewed by ICCS Quality and Standar
![Kappa and lambda immunohistochemistry and in situ hybridization in the evaluation of atypical cutaneous lymphoid infiltrates - Hristov - 2020 - Journal of Cutaneous Pathology - Wiley Online Library Kappa and lambda immunohistochemistry and in situ hybridization in the evaluation of atypical cutaneous lymphoid infiltrates - Hristov - 2020 - Journal of Cutaneous Pathology - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/682f4ccc-f7aa-4d0f-a62d-de5f2d44a6b4/cup13858-fig-0001-m.jpg)
Kappa and lambda immunohistochemistry and in situ hybridization in the evaluation of atypical cutaneous lymphoid infiltrates - Hristov - 2020 - Journal of Cutaneous Pathology - Wiley Online Library
Excluding myeloma diagnosis using revised thresholds for serum free light chain ratios and M-protein levels | Haematologica
Excluding myeloma diagnosis using revised thresholds for serum free light chain ratios and M-protein levels | Haematologica
![Table 2 from Prevalence and clinical significance of abnormal serum kappa/lambda light chain ratio in patients with chronic kidney disease. | Semantic Scholar Table 2 from Prevalence and clinical significance of abnormal serum kappa/lambda light chain ratio in patients with chronic kidney disease. | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/1444d9fcd1aa06934208ca29e69340f3ca084cbe/3-Table2-1.png)
Table 2 from Prevalence and clinical significance of abnormal serum kappa/lambda light chain ratio in patients with chronic kidney disease. | Semantic Scholar
![PDF) Serum Free Light Chain Assay and κ/λ Ratio: Performance in Patients With Monoclonal Gammopathy-High False Negative Rate for κ/λ Ratio PDF) Serum Free Light Chain Assay and κ/λ Ratio: Performance in Patients With Monoclonal Gammopathy-High False Negative Rate for κ/λ Ratio](https://www.researchgate.net/profile/Gurmukh-Singh-2/publication/311492262/figure/tbl4/AS:614118352486425@1523428633662/Poor-Performance-of-SFLCA-k-l-Ratio-in-a-Patient-With-IgG-Lambda-Myeloma_Q320.jpg)
PDF) Serum Free Light Chain Assay and κ/λ Ratio: Performance in Patients With Monoclonal Gammopathy-High False Negative Rate for κ/λ Ratio
![Frontiers | Case Report: A case of IgD lambda/lambda Multiple Myeloma in patient with acute renal failure and without monoclonal spike in serum electrophoresis Frontiers | Case Report: A case of IgD lambda/lambda Multiple Myeloma in patient with acute renal failure and without monoclonal spike in serum electrophoresis](https://www.frontiersin.org/files/Articles/974392/frhem-01-974392-HTML/image_m/frhem-01-974392-g001.jpg)
Frontiers | Case Report: A case of IgD lambda/lambda Multiple Myeloma in patient with acute renal failure and without monoclonal spike in serum electrophoresis
![PDF] Reference values for immunoglobulin kappa and lambda light chains and the kappa/lambda ratio in children's serum. | Semantic Scholar PDF] Reference values for immunoglobulin kappa and lambda light chains and the kappa/lambda ratio in children's serum. | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/062e85a70c6f2d44975de989760becdae280cc49/3-Figure2-1.png)
PDF] Reference values for immunoglobulin kappa and lambda light chains and the kappa/lambda ratio in children's serum. | Semantic Scholar
![PDF) Serum Free Light Chains in Neoplastic Monoclonal Gammopathies: Relative Under-Detection of Lambda Dominant Kappa/Lambda Ratio, and Underproduction of Free Lambda Light Chains, as Compared to Kappa Light Chains, in Patients With PDF) Serum Free Light Chains in Neoplastic Monoclonal Gammopathies: Relative Under-Detection of Lambda Dominant Kappa/Lambda Ratio, and Underproduction of Free Lambda Light Chains, as Compared to Kappa Light Chains, in Patients With](https://www.researchgate.net/publication/325548624/figure/tbl2/AS:669120525787137@1536542173032/Distribution-of-Patients-With-Neoplastic-Monoclonal-Gammopathies-With-SFLCA-Results_Q320.jpg)
PDF) Serum Free Light Chains in Neoplastic Monoclonal Gammopathies: Relative Under-Detection of Lambda Dominant Kappa/Lambda Ratio, and Underproduction of Free Lambda Light Chains, as Compared to Kappa Light Chains, in Patients With
![PDF) The cut-offs for kappa/lambda ratio in bone marrow immunohistochemistry for the diagnosis of multiple myeloma PDF) The cut-offs for kappa/lambda ratio in bone marrow immunohistochemistry for the diagnosis of multiple myeloma](https://www.researchgate.net/publication/343542653/figure/tbl2/AS:934204644798465@1599743152230/Accuracy-of-different-kl-ratio-cut-offs-for-multiple-myeloma-diagnosis_Q320.jpg)
PDF) The cut-offs for kappa/lambda ratio in bone marrow immunohistochemistry for the diagnosis of multiple myeloma
![PDF] Serum Free Light Chain Assay and κ/λ Ratio: Performance in Patients With Monoclonal Gammopathy-High False Negative Rate for κ/λ Ratio | Semantic Scholar PDF] Serum Free Light Chain Assay and κ/λ Ratio: Performance in Patients With Monoclonal Gammopathy-High False Negative Rate for κ/λ Ratio | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/3580b5fcf5c802b8beeffb4ea5e1813f205cdf3f/6-Table6-1.png)